Exposure to ambient air pollutants during pregnancy is linked to IL4, IL10, and IFNγ gene methylation and fewer Th1, Th2, and Th17 cell populations

Ambient air pollutants(AAPs) have been linked with adverse pregnancy outcomes, such as preeclampsia, preterm labor, and low birth weight. During pregnancy, there is an attenuation in cell-mediated immunity with shifts in the Th1/Th2/Th17/Treg environment, contributing to overall maternal susceptibility.