Pos-340 mapk1 mediates high glucose induced renal tubular injury through disrupting the integrity of mam

S. Liu,H. Chen,C. Wang, Q. Xu, S. Feng,Y. Wang, J. Yao, Q. Zhou, C. Tong, B. Yang, J. Chen,H. Jiang

Kidney International Reports（2022）

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摘要

Diabetic kidney disease (DKD) is the main reason of end-stage renal disease (ESRD), while the underlying etiopathogenesis of DKD is unclear. Recent studies showed Mitochondria-associated endoplasmic reticulum membranes (MAM) might serve as a key regulator in the control of glucose homeostasis. Kidney is an important target of hyperglycemic damage, but few studies have been done on the role of MAM in DKD.

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