Metal-free synthesis of N-sulfonylformamidines via skeletal reconstruction of sulfonyl oximonitriles
Organic Chemistry Frontiers(2022)
摘要
We developed for the first time an unprecedented domino reaction of sulfonyl oximonitriles with secondary amines to streamline the synthesis of N-sulfonylformamidines in decent to high yields under mild reaction conditions. In addition, scale-up experiments and late-stage functionalization of drugs were also performed. Preliminary studies indicate that the loss of a cyano-/benzyloxy-group and a sulfonyl migration process are involved in this reaction.
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