Meta‐analysis of agreement/concordance statistics in studies comparing self‐ versus clinician‐collected samples for HPV testing in cervical cancer screening

We conducted a meta-analysis of test agreement/concordance between human papillomavirus (HPV) testing in self-collected versus clinician-collected samples in 26 studies (10,071 participants) updating a previous meta-analysis on accuracy for cervical precancer. Pooled overall agreement was 88.7% (95%CI: 86.3%-90.9%), positive agreement was 84.6% (95%CI: 79.9%-88.7%), negative agreement was 91.7% (95%CI: 89.1%-94.0%), and kappa was 0.72 (95%CI: 0.66-0.78). Subgroup meta-analyses suggested higher overall agreement for target amplification-based DNA assays (90.4%) compared to signal amplification-based DNA assays (86.7%) (p=0.175) or RNA assays (82.3%) (p<0.001). HPV test agreement/concordance targets may provide criteria to extend existing validations towards alternative sampling approaches and devices/storage media. This article is protected by copyright. All rights reserved.