Mapping the regulatory landscape of membraneless organelle assembly and dynamics

Membraneless organelles (MLOs) are an elusive class of cellular structures that intersect diverse cellular pathways and have been implicated in multiple pathologies, including neurodegeneration and cancer. A defining feature of MLOs is their assembly through molecular condensation, which creates a dynamic range of material properties. Understanding how molecular condensation is regulated within a living system is essential for defining how these unique cellular structures function in homeostasis and how their dysregulation is linked to disease.