Roles of chromatin many-body 3D interactions in concurrent regulation of multiple genes at eQTL loci

Chromatin folding plays important roles in the regulation of gene expression, which control cellular activities and are the basis of differentiation. With long-range chromatin interactions, genomic variants far away from the target gene may be important contributors affecting its expression. However, the mechanisms through which distal mutations modulate gene expression are not well studied. In this study, we investigate how expression quantitative trait loci (eQTLs), which identifies mutations associated with variation in gene expression, may exert their effects through chromatin 3D interactions.