Indexing Estimates of Glomerular Filtration Rate to Body Surface Area in Low-Resource Settings with a High Burden of Malnutrition: Evidence from Guatemala

In clinical and epidemiologic practice, estimated glomerular filtration rate (eGFR) is most often calculated using serum creatinine-based equations, such as the Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation.1,2 There is considerable global variability in the accuracy of these equations, which have largely been developed and validated in high-income settings. Some of the variability can be explained by genetic differences in renal function, dietary habits, body composition, and age distribution of the population, among other factors.