Changes in Gut Microbiome Composition with Healthy Aging in Humans: Links to Vascular Endothelial Function.

Nathan Greenberg,Marissa L Burnsed-Torres,Antonio Gonzalez,Abigail G Casso,Kara L Lubieniecki,Brian P Ziemba,Matthew J Rossman,Emily C Adam,Michel Chonchol,Kevin P Davy,Rob Knight,Douglas R Seals,Vienna E Brunt

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

Our findings represent initial evidence in humans that the gut microbiome changes with healthy aging and may be an important mediator of age-related endothelial dysfunction, possibly via increasing circulating LPS and vascular inflammation.

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