Lipocalin-2 Stimulates Proliferation and a Profibrotic Cholangiocyte Phenotype during Cholestasis.

April O'Brien,Danaleigh Stiles,Tori White, Matthew Lopez,Ashleigh Little,Jonathan Childs, Ashley Douthitt,Thien Phan,Abigail Medford,Lixian Chen,Heather Francis,Gianfranco Alpini,Sanjukta Chakraborty,Shannon Glaser

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

LCN2 and 24p3-R expression is elevated in cholestatic models and stimulates a profibrotic cholangiocyte phenotype. These findings suggest that LCN2 may play a crucial role in the pathogenesis of cholestatic liver injury.

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