Epigenetic regulation of Anoctamin1 in pulmonary arterial hypertension.

Natalie M D'Silva,Eric R Wang,Ana Fernandez-Nicolas,Alexander Vang,Naohiro Yano,Alexsandra Zimmer,Alexey V Fedulov, Peng Zhang,Gaurav Choudhary

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

Our results demonstrate that DNA methylation in human ANO1 gene is significantly altered in PAH and reduction in DNA methylation may serve as a regulatory mechanism for ANO1 upregulation in settings of PAH.

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