Role of Locus Coeruleus Expressing Angiotensin Type 1 Receptors (AT1R) Neurons in Fear Learning and Stress-Induced Anxiety

These findings provide evidence for a novel angiotensinergic LC cell type and position the LC AT R as a potential mediator of noradrenergic regulation in learned fear and stress-induced anxiety. Future studies are needed to fully characterize the underlying neurocircuits and neuropeptide modulators that likely interact with the LC AT R expressing neurons during stress-related behaviors.