Novel Mediators of Reelin Signaling in Human Vascular Endothelial Cells.

Beryl Khakina,Ellen Scott,Cameron Jeffers,Cathy J Hatcher

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

We conclude that ADAMTS1 mRNA is upregulated in RELN KD HDMECs versus negative control cells. Knockdown of RELN in HDMECS altered cell migration, membrane permeability, capillary-like tube formation and expression of angiogenic transcripts. These findings provide key evidence that ADAMTS1 and other angiogenic transcripts may be novel mediators of Reelin signaling in human vascular endothelial cells.

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