Transcriptomic Profiling Reveals Mesolimbic Gene Targets Associated with Oxycodone-Seeking During Abstinence.

The results of the present study identified unique differences in the transcriptomic landscape of key nodes in the mesolimbic circuitry following abstinence from saline or oxycodone self-administration. In addition, the shared differentially expressed genes within the opioid signaling pathway (i.e., GNAS) provide prioritized candidates for future pharmacotherapeutics aimed to help maintain abstinence from oxycodone and prevent relapse in OUD.