R-(-)2,5-dimethoxy-4-iodoamphetamine (DOI) Blunts the Discriminative Stimulus Properties of Oxycodone.

Leah M Salinsky,Robert Fox,Noelle Anastasio,Kathryn A Cunningham

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

The current studies reveal that the psychedelic DOI does not substitute for oxycodone, but does suppress the stimulus effects of oxycodone, an effect which is reversed by the 5-HT R antagonist M100907. Taken together, these studies provide support for expanded interrogation of the efficacy of 5-HT R agonists in counteracting the behavioral effects of opioids.

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