Smooth Muscle-Specific Deletion of Neuropilin-1 Increases Vascular Contractility and Blood Pressure.

Dakshnapriya Balasubbramanian,George Lambrinos,Vivian Cristofaro,Alexander Bigger-Allen,Beibei Wang,Yao Gao,Hong Chen,Rosalyn M Adam,Maryrose P Sullivan,Diane R Bielenberg

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

Together, our data point to the role of NRP1 as a novel regulator of basal vascular tone and blood pressure, and the loss of NRP1 leads to the onset of hypertension and exacerbates pathological vascular remodeling and cardiac dysfunction.

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