Chemotherapy, Microvascular Function, and Angiogenesis - a Longitudinal Study.

Our data show pathological impairment in angiogenic potential and gene expression in adipose tissue of breast cancer patients in a longitudinal study. These data support our observed defects in MV function (response to FMD and Ach) during and after CTx treatment. We observed significant reductions in MV function and capillary sprouting during treatment with CTx in the absence of a clinically relevant reduction in cardiac function. Our findings suggest that CTx-induced MV dysfunction precedes and may contribute to future adverse CV events.