Gut commensal Coprococcus comes diminishes the blood pressure-lowering effect of ester angiotensin-converting enzyme inhibitors.

These observations constitute the first report of an unrecognized role of a select gut microbe, C. comes, in reducing the effectiveness of ester ACEi. As such, this mechanistic study serves as the foundation for expanding clinical management of antihypertensive drug resistance via manipulation of gut microbiota.