The ErbB3 Receptor Restricts Bmi1 to Regulate Paneth Cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）
摘要
Our data demonstrate that ErbB3 regulates Bmi1 expression through PI3K/Akt and MAPK signaling in both human and mouse intestinal cells. Furthermore, BMI1 activity promotes LYZ1 expression. Together, these results support our hypothesis that ErbB3 regulates secretory cell differentiation through BMI1 in the intestinal epithelium.
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