The Minichromosome Maintainance Complex is Up-Regulated in the Placentas of Low-Insulin Sensitive Mothers in the First Trimester of Pregnancy

Julia Bandres-Meriz, Irene Hurtado,Alejandro Majali-Martinez,Denise Hoch,Sophie Honeder,Ruth Birner-Grünberger,Louise T Dalgaard,Gernot Desoye

REPRODUCTIVE SCIENCES（2022）

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摘要

Low insulin sensitivity of pregnant women in in the early first trimester of pregnancy associated with obesity induced changes in the placental proteome related to DNA replication and cell cycle. This may reflect trophoblast response to increased DNA damage in these placentas.

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