The Effect of Lipolysis Inhibitor Acipimox on Brown Adipose Tissue Bioenergetics and Uncoupling Protein Abundance in Severely Burned Rats.

Victoria G Rontoyanni,Amina El Ayadi,Anesh Prasai,Ye Wang,Nisha Bhattarai,Emre Vardarli,Craig Porter,Andrew J Murton

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

BAT UCP1 function than UCP1 protein content is greater in severely burned rats. Acipimox appears to reduce UCP1-dependent respiration, independent of UCP1 protein levels. The effect of acipimox on BAT ANT2 protein content may partly explain the absence of an effect on UCP1-independent respiration, but this warrants further investigation. The protocol was approved by the University of Texas Medical Branch IACUC.

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