Amyloid-Beta Precursor Protein: Essential to Lung Capillary Barrier Defense During Acute Infection.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2022)

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摘要
Lung endothelial APP is an important contributor to host defense. Both APP and its Aβ variant(s) appear to constrain infective bacterial burden whereas APP products appear to function as mitogens/morphogens within the microvascular milieu, likely contributing to tissue repair and recovery post-insult.
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