Activation of Leptin-Receptor-Expressing eurons in the Dorsomedial Hypothalamus Increases Hypercapcnic Ventilatory Response and Relieves Obstructive Sleep Apnea in Obese Mice

Mateus R. Amorim,Xin Wang,Huy Pho,Shannon Bevans-Fonti,Frederick Anokye-Danso,Joan Escobar,Olga Dergacheva,G. Luiz,S. Branco,David Mendelowitz,Vsevolod Y. Polotsky

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

Leptin up-regulates the hypercapnic ventilatory response and upper airway patency during sleep acting on LEPR neurons in the DMH. Respiratory effects of leptin are likely mediated via projections of these neurons to the dorsal raphe.

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