Central and Systemic Effects of Subdiaphragmatic Vagus Nerve Stimulation during the Development of Hypertension in the SHR.

Chronic intermittent sdVNS can delay but not prevent the onset of HTN in the SHR. This delay does not coincide with changes in systemic inflammatory markers or gut bacterial composition; however, changes in the NTS transcriptome indicate afferent rather than efferent effects of chronic intermittent sdVNS in the SHR. Future studies will dissect precise central effects of afferent gut-brain communication.