Pathophysiology of Venous Thromboembolism: Putative role of HDL.

Low levels of HDL proteins along with high levels of adhesion molecules, thrombotic markers and inflammatory molecules indicate the suppression of HDL activity. High lipooxygenase enzymes and oxidized lipoprotein levels support the hypothesis of dysfunctional HDL. HDL isolated from the ligated group was unable to prevent the LDL oxidation which clarifies that HDL loses its functionality in case of VTE. Furthermore, finding of this study will also help in understanding the pathophysiology of VTE which might give an insight in prevention/early diagnosis of the disease.