A Role for the Adrenal Clock in Aldosterone Regulation and Renal Excretory Function

Consistent with our hypothesis, loss of the core clock protein BMAL1 in the ZG of the adrenal gland resulted in blunted night/day aldosterone levels and disturbance in renal Na handling. This work is the first to investigate the role of adrenal BMAL1 on aldosterone regulation and renal function, suggesting a link between the adrenal clock and the kidney. Future studies will assess whether BP rhythm in AS-BMAL1 KO mice is disrupted and determine if there are sex-specific differences in the role of adrenal BMAL1.