Alterations in hepatic albumin phosphorylation in patients with alcohol-associated hepatitis and cirrhosis.

Josiah Hardesty,Le Day,Jeffrey Warner,Kara Zirnheld,Dennis Warner,Jon Jacobs,Craig McClain,Irina Kirpich

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

This study demonstrated that hepatic ALBU levels are elevated in AH and AC, likely due to the loss of pS82 phosphorylation by FA20A/C, compromising hepatocellular ALBU release. Altered ALBU phosphorylation and subsequent release could be a key pathogenic mechanism of hypoalbuminemia in AH and AC. Further studies are warranted to test this hypothesis.

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