Maresin 1 improves cognitive decline and ameliorates inflammation and blood-brain barrier damage in rats with chronic cerebral hypoperfusion

Tian Li,Jiaxin Zheng,Zhitian Wang, Lingling Xu,Dong Sun,Hao Song,Shenjia Wu, Miaoyu Du,Sisi Peng,Junjian Zhang

Brain Research（2022）

引用 6|浏览8

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摘要

•Maresin1 (MaR1) can improve cognitive impairment in chronic cerebral hypoperfusion (CCH) rats.•MaR1 can ameliorate neuroinflammation caused by CCH.•MaR1 can attenuate hippocampal blood–brain barrier (BBB) damage of CCH rats, which may improve cognition in CCH rats by MaR1.

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关键词

BBB,CCH,VCI,2VO,mNSS,Maresin1,EB,TEM,MMP-9,ZO-1,MWM,TNF-α,IL-1β,NF-κB

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