Sexual Dimorphic Regulation of MicroRNAs Alters Sodium Transport in the Kidney Distal Nephron.

Corinne E Farrell,Xiaoning Liu,Nejla Ozbaki Yagan,Stephanie Mutchler,Andrew J Bodnar,Jacqueline Ho,Michael Butterworth

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

The miR-17~92 cluster is regulated by aldosterone and estrogen. Mir-19 targets SGK1 and may account for estrogen's inhibition of aldosterone signaling. This miR cluster may be responsible, in part, for the observed sex-specific differences in aldosterone signaling. Ongoing studies aim to determine if altering the expression of miR-17~92 disrupts RAAS signaling in the kidney in vivo.

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