T Cells Contribute to Lipid Deposition in Male and Female Dahl Rats Fed a High Saturated Fat Diet.

These data confirm the hypothesis that T cell KO prevents the HFD-induced increases in adiposity in the liver and gonadal adipose tissue. Lipid deposits in these areas are detrimental for cardiovascular health. Lipid deposition in the liver is a strong predictor of insulin resistance. Furthermore, chronic ingestion of a HFD increases adipose tissue expansion, which promotes inflammation and oxidative stress. Since the majority of Americans are consuming large amounts of fat, investigating the mechanisms underlying HFD-induced adiposity will help identify targets to improve cardiovascular health.