NOTCH-YAP1/TEAD-DNMT1 Axis Drives Hepatocyte Reprogramming Into Intrahepatic Cholangiocarcinoma

Shikai Hu,Laura Molina,Junyan Tao,Silvia Liu,Mohammed Hassan,Sucha Singh,Minakshi Poddar,Aaron Bell,Daniela Sia,Michael Oertel,Reben Raeman,Kari Nejak-Bowen,Aatur Singhi,Jianhua Luo,Satdarshan P Monga,Sungjin Ko

Gastroenterology（2022）

引用 19|浏览24

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摘要

We identify a subset of intrahepatic bile duct cancers to originate from hepatocytes instead of bile duct cells, and identify the epigenetic molecular basis of this fatal disease.

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关键词

Liver Cancer,Bile Duct,Precision Medicine,Transdifferentiation,Epigenetics

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