Mesenchymal stem cells attenuate sepsis-associated acute kidney injury by changing the balance of Th17 cells/Tregs via Gal-9/Tim-3.

Congjuan Luo,Feng Luo,Xiaofei Man,Xuemei Liu,Long Zhao,Lin Che,Wei Zhang,Junjie Guo,Shixia Cai,Dawei Wang,Yan Xu

Current stem cell research & therapy（2022）

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摘要

Treatment with MSCs can protect against SA-AKI. The results suggested that the relieving effect of MSCs against SA-AKI may be partially mediated by the induction of Tregs and inhibition of Th17 cells via the Gal-9/Tim-3 pathway.

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关键词

Gal-9/Tim-3,Mesenchymal stem cells,Th17 /Tregs,sepsis-associated acute kidney injury

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