The early-life stress induced by oxytocin inhibition in p53 knockout mouse dams increases adulthood tumorigenesis in first and second generations.

Massimo Stendardo,Chiara Renzi,Rani Pallavi,Niccolò Roda,Valentina Gambino,Francesca Casciaro,Giuseppe Persico,Marco Giorgio

Cancer reports (Hoboken, N.J.)（2023）

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摘要

Therefore, the inhibition of OT function in mothers is a novel paradigm of early-life stress that is inherited across generations and increases cancer risk in tumor-prone mice.

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关键词

cancer risk factor,early-life stress,oxytocin,p53 KO mice,parental care

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