PARP1-PKM2 Axis Mediates Right Ventricular Failure Associated With Pulmonary Arterial Hypertension

Tsukasa Shimauchi,Olivier Boucherat,Tetsuro Yokokawa,Yann Grobs,WenHui Wu,Mark Orcholski,Sandra Martineau,Junichi Omura,Eve Tremblay,Kana Shimauchi,Valérie Nadeau,Sandra Breuils-Bonnet,Roxane Paulin,François Potus,Steeve Provencher,Sébastien Bonnet

JACC: Basic to Translational Science（2022）

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摘要

•In PAH, PARP1 promotes cardiomyocyte dysfunction by impacting PKM2/NF-kB axis•Pharmacological inhibition of PARP1/activation of PKM2 prevent RV dysfunction in PAB rats•Global inactivation of Parp1 confers protection against PAB-induced RV dysfunction•Cardiomyocyte-targeted inactivation of Parp1 attenuates Su/Hx-induced RV dysfunction•Targeting PARP1/PKM2 may represent a promising avenue to support RV function in PAH

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关键词

PARP1,PKM2,pulmonary hypertension,right ventricle

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