Stress-driven method bio-inspired by long bone structure for mechanical part mass reduction by removing geometry at macro and cell-unit scales

•Proposed mass reduction method is bio-inspired from long bones, from both medullar cavity and trabecular bone structures.•Test was carried out to compare the mechanical performances offered by the method with topology optimization at equal mass.•Presented 2.5D torsion disc mass was reduced by 60% compared to the initial disc.•Bio-inspired design of the sample is 27% stiffer, at equal mass, than the one obtained through topology optimization.