Evaluation of the Relationship Between Hyperemesis Gravidarum With Hemoglobin to Red Cell Distribution Width Ratio and Eosinophil to Lymphocyte Ratio

Introduction: This study, it was aimed to investigate the relationship between the severity of hyperemesis gravidarum (HEG) disease and subclinical inflammatory factors such as Hemoglobin to red cell distribution width ratio (HRR), platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), monocytes to lymphocyte ratio (MLR), eosinophil to lymphocyteratio (ELR), which are known to be closely associated with inflammation in patients with hyperemesis gravidarum.Material method: This retrospective case control study was conducted between December 2020 and December 2021. A total of 215 pregnant women, 121 with hyperemesis gravidarum and 94 healthy pregnant women, were included in the study. HEG patients were divided into three groups according to the modified PUQE classification as mild (n=38), moderate (n=41), and severe (n=42).Results: HRR, PLR, NLR, and MLR values were found to be statistically significantly higher in the HEG group compared to the control group, and ELR values were lower (p<0.05). MON, NEU, PCT, PLR, NLR, MLR values increase from mild to severe in HEG patients. EO, LYM, and ELR values decreased (p<0.05). There was a positive correlation between HEG and PCT (rho=0.45, p< 0.001), PLR (rho=0.76, p< 0.001), NLR (rho=0.79, p< 0.001), MLR (rho=0.81, p< 0.001) values. There was a significant negative correlation between ELR (rho= 0.72, p< 0.001) and HEG.Conclusion: NLR, PLR, and PCT are inflammatory markers that increase in patients with HEG and have predictive value for HEG development. In our study, we suggested the use of two new prognostic markers for patients with HEG. We think that our study will be a source for further studies on the subject.