Screening Developability and Pre-Formulation of Biotherapeutics with High-Throughput Dynamic Light Scattering (HT–DLS)

One of the primary technologies for assessing aggregation, stability and viscosity of biotherapeutics, from proteins and peptides to attenuated viruses, is dynamic light scattering (DLS). DLS measures particle size and size distributions, from less then a nanometer and up to several microns, without perturbing the sample. The measurement takes place on time scales of seconds to minutes, and the sample is fully recoverable. This makes DLS a particularly effective technique for assessing aggregation and stability in early as well as late stages. In addition, viscosity can be measured via DLS using probe particles such as common polystyrene latex beads. HT-DLS Maximizes Productivity