Hypoxia promotes local immunosuppression and downregulates type I interferon (IFN)

Department of Medical Oncology, Molecular Oncology Laboratories, Weatherall Institute of 5 Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK 6 Current address: Cambridge Institute for Therapeutic Immunology & Infectious Disease. 7 Jeffrey Cheah Biomedical Centre. Puddlecombe Way, Cambridge, CA CB20AW, UK 8 Department of Oncology, Old Road Campus Research Building, University of Oxford, 9 Oxford, OX3 7DQ, UK 10 Medical Research Council Human Immunology Unit, Medical Research Council Weatherall 11 Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, 12 Oxford OX3 9DS, UK. 13 Current address: Division of Infectious Diseases and Vaccinology, School of Public Health, 14 University of California, Berkeley, USA. 15 Radcliffe Department of Medicine, Weatherall Institute of Molecular Medicine, University of 16 Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK 17 18 equal contribution 19