Rapid and accurate identification of SARS-CoV-2 Omicron variants using droplet digital PCR (RT-ddPCR)

Margaret G Mills,Pooneh Hajian,Shah Mohamed Bakhash,Hong Xie,Derrek Mantzke,Haiying Zhu,Garrett A Perchetti,Meei-Li Huang,Gregory Pepper,Keith R Jerome,Pavitra Roychoudhury,Alexander L Greninger

medRxiv（2022）

引用 9|浏览8

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摘要

•Some mutations in SARS-CoV-2 Spike correlate with immune evasion in many variants.•RT-ddPCR can quickly and accurately identify these causative single base mutations.•An assay designed for earlier variants is able to distinguish Omicron subvariants.•The RT-ddPCR assay is both accurate and fast enough for clinical decision-making.

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B.1.1.529,Allelic discrimination

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