Toward an Understanding of the Functional Connectomics of Affective and Psychotic Illness

Converging evidence indicates that the boundaries separating nominally distinct psychiatric diagnoses are not sharp or discontinuous with normal behavioral traits and brain function. In healthy populations, individual differences in behavior are reflected in variability across the collective set of functional brain connections (functional connectome). Here, we present initial efforts to build a large, open repository of structural and functional neuroimaging data to characterize discrete and transdiagnostic network features that link individual variation in functional connectomes with symptom profiles across affective and psychotic illnesses.