Chronic Exposure to Psychostimulants in Pediatric ADHD Moderates Striatal Resting-State Functional Connectivity and Symptom Severity Over Two Years

Acute administration of psychostimulants, the most common medication for Attention-Deficit/Hyperactivity Disorder (ADHD), attenuates symptoms via upregulation of striatal dopamine activity. Less is known about the effects of long-term psychostimulant exposure. We explored exposure-dependent changes in striatal resting-state functional connectivity (rs-FC) and their relation to symptom outcome across two years in the Adolescent Brain Cognitive Development dataset.