On Indocyanine Green Fluorescence and Autofluorescence in thyroid and parathyroid surgery: A systematic review

Review question / Objective: Autofluorescence (AF) and Indocyanine Green Fluorescence (ICG) were used for the first time for parathyroid gland (PG) identification in 2011 and 2015, respectively, during thyroidectomy/parathyroidectomy. Authors reported promising results. We aim to understand the efficacy, technical challenges, cost-effectiveness, and impact on postoperative biochemical and clinical outcomes of such new techniques. Eligibility criteria: The language filter was set to allow for publications in English, German, Spanish, and French assessing the use of ICG and/or AF for PG identification. Only titles and abstracts, followed by the full text dating from 2008 to 2020 have been considered in this review. Existing systematic reviews were excluded from the results.