Title : The Heterochromatin protein 1 is a master regulator in RNA splicing 1 precision deficient in ulcerative colitis 2

1Department of Immunology, Infectiology and Hematology, Institut Necker-Enfants 8 Malades (INEM), INSERM U1151, CNRS UMR 8253, Université Paris Descartes, 9 Paris, France. 10 2Proteomic Platform Necker, PPN-3P5, Structure Fédérative de Recherche SFR 11 Necker US24, 75015 Paris, France 12 3Grupo de Nanomedicina. Universidad de Cantabria-IDIVAL, Herrera Oria s/n, 13 39011, Santander, Spain 14 4National Institute for Agronomic Research (INRA), Unit on Ecology and Physiology 15 of the Digestive Tract (UEPSD), 78352, Jouy-en-Josas Cedex, France 16 5Institut National de la Recherche Agronomique (INRA), MICALIS, UMR, Pôle 17 Ecosystèmes, Jouy-en-Josas, France 18 6APHP/INSERM UMR 1149, équipe inflammation Intestinale UFR de Médecine, 19 Xavier Bichat Université de Paris 20 7Institut de Biologie Paris-Seine, Sorbonne Université, CNRS UMR 8256, Biological 21 Adaptation and Aging, Paris, France Paris, France 22 8Dept of Biosciences and Nutrition, Karolinska Institutet, SE-141 57 Huddinge, 23 Sweden. 24