NLRP 3 inflammasome priming and activation are regulated by 2 a novel phosphatidylinositol-dependent mechanism 3 4

Claire Hamilton1,#, Antoni Olona1,#, Stuart Leishman1, Kelly MacDonald-Ramsahai1, 5 Shamshad Cockcroft2, Gerald Larrouy-Maumus3, and Paras K. Anand1,* 6 7 8 1Department of Infectious Disease, Imperial College London, London, W12 0NN, UK. 9 2Department of Neuroscience, Physiology and Pharmacology, Division of Biosciences, 10 University College London, London WC1E 6JJ, UK. 11 3MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial 12 College London, London, SW7 3AZ, UK. 13 14 15 16 *Corresponding author 17