Early complications in pediatric hematopoietic stem cell transplantation

The conditioning regimens used in HSCT are known to have a high emetogenic risk. Nausea and vomiting are some of the most feared adverse effects of chemotherapy and radiotherapy. Studies show that administering prophylactic regimens concordant with published guidelines significantly reduces and controls symptoms for patients receiving moderately or highly emetogenic treatment. Focused on the prevention, guidelines recommend a combination of aprepitant, dexamethasone and a serotonin antagonist in pediatric patients.2,4