Hologram optogenetic illumination with a few pixel SLM

A novel CGH algorithm is proposed for targeted neural stimulation using a few pixel Spatial Light Modulator (SLM) device. This is achieved with the elaboration of standard CGH design algorithms to include a regularized cost function for the discretization of phase and amplitude. The regularized cost function is appropriate for designing holographic masks that can be realized using a few pixel SLM. It is anticipated that these results will contribute to the research efforts towards a portable in vivo optogenetic system.