miR143-3p–Mediated NRG-1–Dependent Mitochondrial Dysfunction Contributes to Olanzapine Resistance in Refractory Schizophrenia

Jing Sun,Xiaoya Zhang, Qijie Cong,Dong Chen,Zhenghui Yi,Hailiang Huang,Cong Wang,Mo Li,Rongsen Zeng,Yunxi Liu,Cong Huai,Luan Chen,Chuanxin Liu, Yan Zhang,Yong Xu,Lingzi Fan,Guoqiang Wang,Chuanfu Song,Muyun Wei,Huihui Du

Biological Psychiatry（2022）

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摘要

Our findings provide direct evidence of olanzapine resistance resulting from NRG-1 deficiency-induced mitochondrial dysfunction, and they link olanzapine resistance and NRG-1 deficiency-induced mitochondrial dysfunction to an NRG-1/miR143-3p axis, which constitutes a novel biomarker and target for TRS.

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关键词

miR143-3p,Mitochondrial dysfunction,Molecular mechanism of olanzapine resistance,Neuregulin-1,NRG-1,TRS

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