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BSL2-Compliant Lethal Mouse Model of SARS-CoV-2 and Variants of Concern to Evaluate Therapeutics Targeting the Spike Protein

Mohanraj Manangeeswaran,Derek D. C. Ireland,Seth G. Thacker,Ha-Na Lee,Logan Kelley-Baker,Aaron P. Lewkowicz,Paul W. Rothlauf,Marjorie Cornejo Pontelli,Louis-Marie Bloyet,Michael A. Eckhaus, Mirian I. Mendoza,Sean Whelan,Daniela Verthelyi

Frontiers in Immunology（2022）

Cited 3|Views1
Key words
SARS-CoV-2,spike protein,neurotropism,BSL-2 mouse model,pseudotyped virus,ACE2 transgenic mice,VSV (vesicular stomatitis virus),COVID-19
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