Ablation of Apparent Diffusion Coefficient Hyperintensity Clusters in Mesial Temporal Lobe Epilepsy Improves Seizure Outcomes after Laser Interstitial Thermal Therapy.

Seizure outcome after LiTT in mTLE patients was significantly associated with the extent of cluster ablation in the amygdalohippocampal complex. The results suggest that preoperative ADC analysis may help identify high-yield pathological tissue clusters that represent epileptogenic foci. ADC-based cluster analysis can potentially assist ablation targeting and improve seizure outcome after LiTT in mTLE.