Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response
bioRxiv(2022)
摘要
The new variant of concern (VOC) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Omicron (B.1.1.529), is genetically very different from other VOCs. We compared Omicron with the preceding VOC Delta (B.1.617.2) and the wildtype strain (B.1) with respect to their interactions with the antiviral type I interferon (IFN-alpha/beta) response in infected cells. Our data indicate that Omicron has gained an elevated capability to suppress IFN-beta induction upon infection and to better withstand the antiviral state imposed by exogenously added IFN-alpha.
### Competing Interest Statement
The authors have declared no competing interest.
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关键词
antiviral type,interferon,sars-cov
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