USP1 inhibition suppresses the progression of osteosarcoma via destabilizing TAZ

USP1 inhibition suppresses the progression of osteosarcoma via destabilizing TAZ 1 Putao Yuan1,2,3 *, Zhenhua Feng1,2, *, Hai Huang1,2,4 *, Gangliang Wang1,2, *, Zhijun 2 Chen1,2,3, Guang Xu1,2, Ziang Xie1,2, Zhiwei Jie1,2, Xiangde Zhao1,2, Qingliang Ma1,2, 3 Shiyu Wang1,2, Yang Shen1,2, Yizhen Huang1,2, Ying Han1,2, Huali Ye1,2, Jiying Wang1,2, 4 Peihua Shi 1,2,3 # and Xuewu Sun1,2,3 # 5 6 1Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University 7 School of Medicine. 8 2Key Laboratory of Musculoskeletal System Degeneration and Regeneration 9 Translational Research of Zhejiang Province. 10 3 Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China. 11 4 903RD Hospital of Pla, Hangzhou, China. 12 13 *These authors contributed equally to this work. 14 #Correspondence to: 15